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Information found on this page is intended for US residents only.
We prioritize trust through action. We’re the first to ground classic psychedelics in the rigorous development pathways of mainstream medicine with the goal of offering providers like you new options for your hardest-to-treat patients.
While clinicians have worked tirelessly to support their patients, current care options for mental health conditions leave millions of patients to cycle through treatments as they search for relief. We recognize this clinical challenge and honor the perseverance of clinicians who keep seeking new answers even as patients stop expecting them.
Like you, we understand that every mental health journey is unique and different. We don’t promise a cure, but rather the prospect of a new approach—one grounded in bringing non-traditional treatments into a rigorous medical and scientific framework. By setting high clinical standards and navigating the regulatory route for psilocybin treatment, we aim to create pathways to activate neuroplasticity, the brain’s inherent capacity for cognitive flexibility and reorganization.
We’re driven to advance potentially clinically meaningful, rapid and durable treatment options based on a robust and meticulously-built evidence base—options designed to empower clinicians, support patient agency, and integrate into mainstream care.
When a patient is diagnosed with TRD, it means their depression has resisted at least two courses of treatment. This resistance increases risks to their health and harm to their quality of life.¹ We are dedicated to these patients who have exhausted the current options and need science to rigorously pursue new possibilities.
PTSD is a condition that may occur in people who have experienced traumatic events,² from combat or assault to accidents or natural disasters. This state of hypervigilance often complicates life with intense comorbid distress. We are committed to your patients whose lives have been devastated by PTSD and seek a path through it.
This status quo is unacceptable to us, and that drives our work forward—for the sake of providers like you and the patients you treat.
$282B
is the annual economic cost of mental illness in the US.3
~50%
of the 61.5M US adults with a mental illness did not receive treatment in 2024.4
1 in 2
is the estimated number of US adult patients with a mental illness who don't adhere to their prescribed course of treatment.5
93%
of behavioral health workers say they've experienced burnout.6
We encourage you to visit clinicaltrials.gov to learn more about our clinical trials.
Go to clinicaltrials.gov
Publications
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Our Work
Learn more1. “Association of Treatment-Resistant Depression with Patient Outcomes and Health Care Resource Utilization in a Population-Wide Study.” JAMA Psychiatry. 14 December 2022. https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2799488
2. “What is PTSD?” American Psychiatric Association. Accessed, 27 May 2026. https://www.psychiatry.org/patients-families/ptsd/what-is-ptsd
3. “Mental Health and the Economy—It’s Costing Us Billions.” Columbia Business School. 28 May 2024. https://business.columbia.edu/insights/business-and-society/mental-health-and-economy-its-costing-us-billions
4. “Annual National Survey on Drug Use and Health.” SAMHSA. 28 July 2025. https://www.samhsa.gov/newsroom/press-announcements/20250728/samhsa-releases-annual-national-survey-on-drug-use-and-health
5. “Psychiatric Patients’ Perceived Health Control and Reactance: Implications for Medication Adherence.” National Library of Medicine. 8 July 2023. https://pmc.ncbi.nlm.nih.gov/articles/PMC10337681/
6. “New Study: Behavioral Health Workforce Shortage Will Negatively Impact Society.” National Council for Mental Wellbeing. 25 April 2023. https://www.thenationalcouncil.org/news/help-wanted/
Information about independent organizations is provided as an additional resource for obtaining information related to mental health conditions. It does not indicate endorsement by Compass Pathways of an organization or its communications. Your healthcare team is your best source of information.
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